Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Dan Sturdevant
PROVIDER: E-GEOD-51699 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Meissner Eric G EG Wu David D Osinusi Anu A Bon Dimitra D Virtaneva Kimmo K Sturdevant Dan D Porcella Steve S Wang Honghui H Herrmann Eva E McHutchison John J Suffredini Anthony F AF Polis Michael M Hewitt Stephen S Prokunina-Olsson Ludmila L Masur Henry H Fauci Anthony S AS Kottilil Shyamasundaran S
The Journal of clinical investigation 20140701 8
BACKGROUND. Hepatitis C virus (HCV) infects approximately 170 million people worldwide and may lead to cirrhosis and hepatocellular carcinoma in chronically infected individuals. Treatment is rapidly evolving from IFN-α-based therapies to IFN-α-free regimens that consist of directly acting antiviral agents (DAAs), which demonstrate improved efficacy and tolerability in clinical trials. Virologic relapse after DAA therapy is a common cause of treatment failure; however, it is not clear why relaps ...[more]