Epigenetic silencing of noncoding RNA nc886 provokes oncogenes during esophageal tumorigenesis
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ABSTRACT: nc886 is a 101 nucleotides long non-coding RNA that is also known as a precursor microRNA or a vault RNA. nc886 has been suggested to be a tumor suppressor, mainly inferred by its expression pattern as well as its genomic location at human chromosome 5q31, a locus for a tumor suppressor gene(s). Pre-clinical study In order to understand potential roles of nc886 in esophageal squamous cell carcinoma (ESCC), we performed the knockdown of nc886 in nonmalignant HET-1A cells and ESCC cell lines (TE-1 and TE-8) and identified and analyzed genes whose expression is activated by nc886 knockdown in ESCC.
ORGANISM(S): Homo sapiens
SUBMITTER: Sangbae Kim
PROVIDER: E-GEOD-51732 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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