Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human patients with aortic aneurysms associated with tricuspid and bicuspid valves

ABSTRACT: Patients with bicuspid aortic valve (BAV) have increased risk of thoracic ascending aortic aneurysm (AscAA) and dissection compared to those with a normal tricuspid aortic valve (TAV). The present study was undertaken to evaluate whether differences in gene expression exist in aortas from BAV and TAV patients with AscAA. Experiment Overall Design: Aneurysmal tissue of ascending aorta was collected from 13 patients with bicuspid aortic valve (BAV) and 12 patients with tricuspid aortic valve (TAV). Patients were selected on the basis of aortic diameter, age and other disease conditions. Patients with giant cell aortitis, cardiovascular abnormalities, inherited connective tissue disorders such as Marfan and Ehlers-Danlos syndrome were excluded from the study. RNA was extracted using Invitrogen RNA extraction kit and shown to be of adequate quality before application to Affymetrix microarray U133A gene chips probing for over 16,000 genes per chip. Two different methods of data analysis were performed: a linear model and GeneSpring.

ORGANISM(S): Homo sapiens

SUBMITTER: Ramanath Majumdar 

PROVIDER: E-GEOD-5180 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Elevated expressions of osteopontin and tenascin C in ascending aortic aneurysms are associated with trileaflet aortic valves as compared with bicuspid aortic valves.

Majumdar Ramanath R   Miller Dylan V DV   Ballman Karla V KV   Unnikrishnan Gopinathan G   McKellar Stephen H SH   Sarkar Gobinda G   Sreekumar Raghavakaimal R   Bolander Mark E ME   Sundt Thoralf M TM  

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20070221 3

<h4>Objective</h4>Ascending aortic aneurysms (AscAAs) are a highly lethal condition whose pathobiology remains to be poorly understood. Although most AscAAs occur in the presence of a trileaflet aortic valve (TAV), a bicuspid aortic valve (BAV) is a common congenital anomaly associated with an increased risk for an AscAA and dissection independent of functional valve pathology but secondary to inherent structural abnormality of the aorta. The objective of this investigation was to compare the pa  ...[more]

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