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Quantitative Genomics study of sex dimorphism in D. Melanogaster

ABSTRACT: A diallel including reciprocals but not selfs experiment. Keywords: Agilent microarray, sexual dimorphism, genetical genomics, genetic variation Nine randomly selected D. melanogaster lines were used as parents for this diallel. Male and female intact adult progeny were collected. Crosses were repeated in four independent sub blocks such that every cross appeared with every other cross at least once. Two sub blocks were pooled for each replicate. Each array was a pair of male and females from the same cross with the dye flipped between replicates

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Lauren McIntyre

PROVIDER: E-GEOD-5181 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Simpler mode of inheritance of transcriptional variation in male Drosophila melanogaster.

Wayne Marta L ML Telonis-Scott Marina M Bono Lisa M LM Harshman Larry L Kopp Artyom A Nuzhdin Sergey V SV McIntyre Lauren M LM

Proceedings of the National Academy of Sciences of the United States of America 20071114 47

Sexual selection drives faster evolution in males. The X chromosome is potentially an important target for sexual selection, because hemizygosity in males permits accumulation of alleles, causing tradeoffs in fitness between sexes. Hemizygosity of the X could cause fundamentally different modes of inheritance between the sexes, with more additive variation in males and more nonadditive variation in females. Indeed, we find that genetic variation for the transcriptome is primarily additive in mal ...[more]

PMID: 18003923

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Quantitative Genomics study of sex dimorphism in D. Melanogaster

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Sexual dimorphism in early osteoclasts demonstrates enhanced inflammatory pathway activation in female cells

Project description:Sexual dimorphism of the skeleton is well documented. At maturity, the male skeleton is typically larger and has a higher bone density than the female skeleton. However, the underlying mechanisms for these differences are not completely understood. In this study, we examined sexual dimorphism in the formation of osteoclasts between cells from female and male mice. We found that the number of osteoclasts in bones was greater in females. Similarly, in vitro osteoclast differentiation was accelerated in female osteoclast precursor (OCP) cells. To further characterize sex differences between female and male osteoclasts, we performed gene expression profiling of cultured, highly purified, murine bone marrow OCPs that had been treated for 3 days with M-CSF and RANKL. We found that 125 genes were differentially regulated in a sex-dependent manner. In addition to genes that are contained on sex chromosomes, transcriptional sexual dimorphism was found to be mediated by genes involved in innate immune and inflammatory response pathways. Furthermore, the NFκB-NFATc1 axis was activated earlier in female early osteoclasts, which partially explains the differences in transcriptomic sexual-dimorphism in these cells. Collectively, these findings identify a sex-dependent intrinsic difference in early osteoclasts, which results from an altered response to osteoclastogenic stimulation. In humans these differences could contribute to the lower peak bone mass and increased risk of osteoporosis that females demonstrate relative to males.

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Immunological Sexual Dimorphism in Placenta and Its Response to Benzene Exposure

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