Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ekihiro Seki
PROVIDER: E-GEOD-51962 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Inokuchi-Shimizu Sayaka S Park Eek Joong EJ Roh Yoon Seok YS Yang Ling L Zhang Bi B Song Jingyi J Liang Shuang S Pimienta Michael M Taniguchi Koji K Wu Xuefeng X Asahina Kinji K Lagakos William W Mackey Mason R MR Akira Shizuo S Ellisman Mark H MH Sears Dorothy D DD Olefsky Jerrold M JM Karin Michael M Brenner David A DA Seki Ekihiro E
The Journal of clinical investigation 20140701 8
The MAP kinase kinase kinase TGFβ-activated kinase 1 (TAK1) is activated by TLRs, IL-1, TNF, and TGFβ and in turn activates IKK-NF-κB and JNK, which regulate cell survival, growth, tumorigenesis, and metabolism. TAK1 signaling also upregulates AMPK activity and autophagy. Here, we investigated TAK1-dependent regulation of autophagy, lipid metabolism, and tumorigenesis in the liver. Fasted mice with hepatocyte-specific deletion of Tak1 exhibited severe hepatosteatosis with increased mTORC1 activi ...[more]