Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression profile of WT and TAK1 KO livers.


ABSTRACT: The effect of ablation of Tak1 gene in the liver was characterized. RNA was extracted from 1-month-old WT and hepatocyte specific TAK1-deleted mice

ORGANISM(S): Mus musculus

SUBMITTER: Ekihiro Seki 

PROVIDER: E-GEOD-51962 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


The MAP kinase kinase kinase TGFβ-activated kinase 1 (TAK1) is activated by TLRs, IL-1, TNF, and TGFβ and in turn activates IKK-NF-κB and JNK, which regulate cell survival, growth, tumorigenesis, and metabolism. TAK1 signaling also upregulates AMPK activity and autophagy. Here, we investigated TAK1-dependent regulation of autophagy, lipid metabolism, and tumorigenesis in the liver. Fasted mice with hepatocyte-specific deletion of Tak1 exhibited severe hepatosteatosis with increased mTORC1 activi  ...[more]

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