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RNA-Seq analysis of human adult peripheral blood populations

ABSTRACT: Generate transcriptomic atlas of healthy peripheral blood subpopulations RNA-Seq performed on sorted granulocytes, monocytes, B-cells, T-cells, total WBC, CD34+ cells Leucegene Project, IRIC

ORGANISM(S): Homo sapiens

SUBMITTER: Guy Sauvageau

PROVIDER: E-GEOD-51984 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo.

Pabst Caroline C Bergeron Anne A Lavallée Vincent-Philippe VP Yeh Jonathan J Gendron Patrick P Norddahl Gudmundur L GL Krosl Jana J Boivin Isabel I Deneault Eric E Simard Jessica J Imren Suzan S Boucher Geneviève G Eppert Kolja K Herold Tobias T Bohlander Stefan K SK Humphries Keith K Lemieux Sébastien S Hébert Josée J Sauvageau Guy G Barabé Frédéric F

Blood 20160201 16

Acute myeloid leukemia (AML) is a genetically heterogeneous hematologic malignancy, which is initiated and driven by a rare fraction of leukemia stem cells (LSCs). Despite the difficulties of identifying a common LSC phenotype, there is increasing evidence that high expression of stem cell gene signatures is associated with poor clinical outcome. Identification of functionally distinct subpopulations in this disease is therefore crucial to dissecting the molecular machinery underlying LSC self-r ...[more]

PMID: 26834243

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