Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Toshi Shioda
PROVIDER: E-GEOD-5200 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Shioda Toshi T Chesnes Jessica J Coser Kathryn R KR Zou Lihua L Hur Jingyung J Dean Kathleen L KL Sonnenschein Carlos C Soto Ana M AM Isselbacher Kurt J KJ
Proceedings of the National Academy of Sciences of the United States of America 20060801 32
To obtain insights into similarities and differences in the biological actions of related drugs or toxic agents, their transcriptomal signature profiles (TSPs) have been examined in a large number of studies. However, many such reports did not provide proper justification for the dosage criteria of each agent. Using a well characterized cell culture model of estrogen-dependent proliferation of MCF7 human breast cancer cells, we demonstrate how different approaches to dosage standardization exert ...[more]