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Molecular markers of breast cancer progression in a MMTV-PyMT hyperplasia transplant mouse model of breast cancer


ABSTRACT: The primary cause of mortality in breast cancer is metastasis, a process which is still poorly understood. To study the process of breast cancer metastasis, we isolated focal hyperplasias from the MMTV-PyMT transgenic breast cancer model and transplanted to syngeneic hosts. The transplants underwent stereotyped progression to adenoma, early carcinoma, and late carcinoma at 5, 8 and 18 weeks post-transplant, respectively. We compared the gene expression profiles of adenomas and late carcinomas by microarray. Analysis of the data revealed that the most differentially expressed gene family between adenomas and late carcinomas were luminal differentiation genes, among them GATA-3. In this report, we characterized the role of GATA-3 in breast cancer. Keywords: spotted oligonucleotide Single hyperplasias were isolated from pubertal MMTV-PyMT x B-actin-GFP mice and transplanted into syngeneic hosts. Total RNA from adenomas (5 week outgrowths) were compared to late carcinomas (18 week outgrowths).

ORGANISM(S): Mus musculus

SUBMITTER: Hosein Kouros-Mehr 

PROVIDER: E-GEOD-5221 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


This study characterized cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) cell lines, tumor specimens, and blood samples. The CD90+ cells, but not the CD90(-) cells, from HCC cell lines displayed tumorigenic capacity. All the tumor specimens and 91.6% of blood samples from liver cancer patients bore the CD45(-)CD90+ population, which could generate tumor nodules in immunodeficient mice. The CD90+CD44+ cells demonstrated a more aggressive phenotype than the CD90+CD44(-) counterpart and  ...[more]

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