Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hosein Kouros-Mehr
PROVIDER: E-GEOD-5221 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Yang Zhen Fan ZF Ho David W DW Ng Michael N MN Lau Chi Keung CK Yu Wan Ching WC Ngai Patricia P Chu Patrick W K PW Lam Chi Tat CT Poon Ronnie T P RT Fan Sheung Tat ST
Cancer cell 20080201 2
This study characterized cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) cell lines, tumor specimens, and blood samples. The CD90+ cells, but not the CD90(-) cells, from HCC cell lines displayed tumorigenic capacity. All the tumor specimens and 91.6% of blood samples from liver cancer patients bore the CD45(-)CD90+ population, which could generate tumor nodules in immunodeficient mice. The CD90+CD44+ cells demonstrated a more aggressive phenotype than the CD90+CD44(-) counterpart and ...[more]