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Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Christopher Vakoc

PROVIDER: E-GEOD-52279 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

Shi Junwei J Whyte Warren A WA Zepeda-Mendoza Cinthya J CJ Milazzo Joseph P JP Shen Chen C Roe Jae-Seok JS Minder Jessica L JL Mercan Fatih F Wang Eric E Eckersley-Maslin Melanie A MA Campbell Amy E AE Kawaoka Shinpei S Shareef Sarah S Zhu Zhu Z Kendall Jude J Muhar Matthias M Haslinger Christian C Yu Ming M Roeder Robert G RG Wigler Michael H MH Blobel Gerd A GA Zuber Johannes J Spector David L DL Young Richard A RA Vakoc Christopher R CR

Genes & development 20131127 24

Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known to suppress tumor formation in several cell types, we found that leukemia cells instead rely on Brg1 to support their oncogenic transcriptional program, which includes Myc as one of its key targets. ...[more]

PMID: 24285714

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