Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Megan Salt
PROVIDER: E-GEOD-52308 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Salt Megan B MB Bandyopadhyay Sourav S McCormick Frank F
Cancer discovery 20131203 2
<h4>Unlabelled</h4>Tumors showing evidence of epithelial-to-mesenchymal transition (EMT) have been associated with metastasis, drug resistance, and poor prognosis. Heterogeneity along the EMT spectrum is observed between and within tumors. To develop effective therapeutics, a mechanistic understanding of how EMT affects the molecular requirements for proliferation is needed. We found that although cells use phosphoinositide 3-kinase (PI3K) for proliferation in both the epithelial and mesenchymal ...[more]