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Brown Adipogenic Reprogramming Induced by a Small Molecule

ABSTRACT: Transcriptome analysis of early adipogenesis induced by basal adipogenesis medium(AM) and AM+Bex for 2 days in C2C12 cells Global gene expression profiling has shown Bex induced adipogenic genes expression change We analyzed 4 samples from basal adipogenesis medium(AM) and AM+Bex(10uM) treated C2C12 cells using the Affymetrix Mouse Gene 1.0 ST platform. Array data was processed by Affymetrix Expression Console and Transcriptome Analysis Console (TAC) software.

ORGANISM(S): Mus musculus

SUBMITTER: Baoming Nie

PROVIDER: E-GEOD-52364 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Brown Adipogenic Reprogramming Induced by a Small Molecule

Project description:Transcriptome analysis of early adipogenesis induced by basal adipogenesis medium(AM) and AM+Bex for 2 days in C2C12 cells Global gene expression profiling has shown Bex induced adipogenic genes expression change

2013-11-15 | GSE52364 | GEO

miRNA profiling of Pax3-FOXO1-C2C12-derived exosomes compared to control C2C12 cells, using the Affymetrix GeneChip miRNA 3.0 array

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Effect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation

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Effect of H19 Knockdown by siRNA on gene expression in C2C12 cells

Project description:We used microarrays to characterize the global changes in gene expression in C2C12 cells due to siRNA knockdown of long non-coding RNA H19 Control siRNA or siRNA specific for mouse H19 were transfected into day1 differentiating C2C12 myoblasts in triplicates. 40 H later total RNAs were isolated and subjected with microarray analysis.

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MUNC downregulation decreases muscle differentiation

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2012-01-03 | E-GEOD-27583 | biostudies-arrayexpress

Role of 14-3-3ζ in the adipogenesis program and the differentiation of healthy adipose tissue

Project description:Obesity is an independent risk factor for diabetes and cardiovascular disease. Before effective anti-obesity therapies can be developed, understanding of what governs the production of healthy versus unhealthy fat tissue is required, as not all types confer equal risk. Adipogenesis requires the precise transduction of signals and coordination of transcription factor cascades. Molecular adaptor proteins of the 14-3-3 family are known to coordinate signaling events from multiple cues, but whether specific isoforms have unique, non-redundant roles in adipogenesis remains unclear. RNAi screening revealed 14-3-3ζ as the critical isoform for in vitro adipocyte differentiation. This study aims to understand the role of 14-3-3ζ in adipogenesis program and the differentiation in health adipose tissue.

2022-03-01 | PXD001215 | Pride

miR-487b, miR-3963 and miR-6412 delayed myogenic differentiation in C2C12 mouse myoblast-derived cells.

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2015-11-24 | E-GEOD-63454 | biostudies-arrayexpress

Real-time quantitative PCR analysis of human liver biopsies from HCV+ patients and healthy donors

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