Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Bruno Di Stefano
PROVIDER: E-GEOD-52396 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Di Stefano Bruno B Sardina Jose Luis JL van Oevelen Chris C Collombet Samuel S Kallin Eric M EM Vicent Guillermo P GP Lu Jun J Thieffry Denis D Beato Miguel M Graf Thomas T
Nature 20131215 7487
CCAAT/enhancer binding protein-α (C/EBPα) induces transdifferentiation of B cells into macrophages at high efficiencies and enhances reprogramming into induced pluripotent stem (iPS) cells when co-expressed with the transcription factors Oct4 (Pou5f1), Sox2, Klf4 and Myc (hereafter called OSKM). However, how C/EBPα accomplishes these effects is unclear. Here we find that in mouse primary B cells transient C/EBPα expression followed by OSKM activation induces a 100-fold increase in iPS cell repro ...[more]