Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Milan Chheda
PROVIDER: E-GEOD-52419 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Chudnovsky Yakov Y Kim Dohoon D Zheng Siyuan S Whyte Warren A WA Bansal Mukesh M Bray Mark-Anthony MA Gopal Shuba S Theisen Matthew A MA Bilodeau Steve S Thiru Prathapan P Muffat Julien J Yilmaz Omer H OH Mitalipova Maya M Woolard Kevin K Lee Jeongwu J Nishimura Riko R Sakata Nobuo N Fine Howard A HA Carpenter Anne E AE Silver Serena J SJ Verhaak Roel G W RG Califano Andrea A Young Richard A RA Ligon Keith L KL Mellinghoff Ingo K IK Root David E DE Sabatini David M DM Hahn William C WC Chheda Milan G MG
Cell reports 20140116 2
Glioblastoma (GBM) harbors subpopulations of therapy-resistant tumor-initiating cells (TICs) that are self-renewing and multipotent. To understand the regulation of the TIC state, we performed an image-based screen for genes regulating GBM TIC maintenance and identified ZFHX4, a 397 kDa transcription factor. ZFHX4 is required to maintain TIC-associated and normal human neural precursor cell phenotypes in vitro, suggesting that ZFHX4 regulates differentiation, and its suppression increases glioma ...[more]