Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Bogi Andersen
PROVIDER: E-GEOD-52648 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Gordon William M WM Zeller Michael D MD Klein Rachel H RH Swindell William R WR Ho Hsiang H Espetia Francisco F Gudjonsson Johann E JE Baldi Pierre F PF Andersen Bogi B
The Journal of clinical investigation 20141027 12
Dermal infiltration of T cells is an important step in the onset and progression of immune-mediated skin diseases such as psoriasis; however, it is not known whether epidermal factors play a primary role in the development of these diseases. Here, we determined that the prodifferentiation transcription factor grainyhead-like 3 (GRHL3), which is essential during epidermal development, is dispensable for adult skin homeostasis, but required for barrier repair after adult epidermal injury. Consiste ...[more]