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DNA methylation profiles of liver and placenta technical replicates

ABSTRACT: We profiled DNA from liver and placenta technical replicate samples on the Illumina HumanMethylation450 BeadChip array. There technical replicates represent a single liver and a single placenta sample. Bisulphite converted DNA was hybridized to Illumina HumanMethylation450 BeadChip arrays

ORGANISM(S): Homo sapiens

SUBMITTER: Martin Aryee

PROVIDER: E-GEOD-52731 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays.

Aryee Martin J MJ Jaffe Andrew E AE Corrada-Bravo Hector H Ladd-Acosta Christine C Feinberg Andrew P AP Hansen Kasper D KD Irizarry Rafael A RA

Bioinformatics (Oxford, England) 20140128 10

<h4>Motivation</h4>The recently released Infinium HumanMethylation450 array (the '450k' array) provides a high-throughput assay to quantify DNA methylation (DNAm) at ∼450 000 loci across a range of genomic features. Although less comprehensive than high-throughput sequencing-based techniques, this product is more cost-effective and promises to be the most widely used DNAm high-throughput measurement technology over the next several years.<h4>Results</h4>Here we describe a suite of computational ...[more]

PMID: 24478339

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DNA methylation profiles of liver and placenta technical replicates

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