Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jason Hackney
PROVIDER: E-GEOD-52772 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Vander Lugt Bryan B Khan Aly A AA Hackney Jason A JA Agrawal Smita S Lesch Justin J Zhou Meijuan M Lee Wyne P WP Park Summer S Xu Min M DeVoss Jason J Spooner Chauncey J CJ Chalouni Cecile C Delamarre Lelia L Mellman Ira I Singh Harinder H
Nature immunology 20131222 2
CD11b(+) dendritic cells (DCs) seem to be specialized for presenting antigens via major histocompatibility (MHC) class II complexes to stimulate helper T cells, but the genetic and regulatory basis for this is not established. Conditional deletion of Irf4 resulted in loss of CD11b(+) DCs, impaired formation of peptide-MHC class II complexes and defective priming of helper T cells but not of cytotoxic T lymphocyte (CTL) responses. Gene expression and chromatin immunoprecipitation followed by deep ...[more]