Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: John White
PROVIDER: E-GEOD-52819 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Verway Mark M Bouttier Manuella M Wang Tian-Tian TT Carrier Marilyn M Calderon Mario M An Beum-Soo BS Devemy Emmanuelle E McIntosh Fiona F Divangahi Maziar M Behr Marcel A MA White John H JH
PLoS pathogens 20130606 6
Although vitamin D deficiency is a common feature among patients presenting with active tuberculosis, the full scope of vitamin D action during Mycobacterium tuberculosis (Mtb) infection is poorly understood. As macrophages are the primary site of Mtb infection and are sites of vitamin D signaling, we have used these cells to understand the molecular mechanisms underlying modulation of the immune response by the hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D). We found that the virul ...[more]