Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Vitamin D treatment of M.tb. infected macrophages


ABSTRACT: As macrophages are the primary site of Mtb infection and are sites of vitamin D signaling, we have used these cells to understand the molecular mechanisms underlying modulation of the immune response by the hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D). Microarrays were used to measure the changes in gene expression induced by 1,25D treatment of H37Rv-infected THP-1 cells Cells were infected at an MOI of 5 or left uninfected, and treated with 10^-7 M 1,25D for 24 hours

ORGANISM(S): Homo sapiens

SUBMITTER: John White 

PROVIDER: E-GEOD-52819 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Vitamin D induces interleukin-1β expression: paracrine macrophage epithelial signaling controls M. tuberculosis infection.

Verway Mark M   Bouttier Manuella M   Wang Tian-Tian TT   Carrier Marilyn M   Calderon Mario M   An Beum-Soo BS   Devemy Emmanuelle E   McIntosh Fiona F   Divangahi Maziar M   Behr Marcel A MA   White John H JH  

PLoS pathogens 20130606 6


Although vitamin D deficiency is a common feature among patients presenting with active tuberculosis, the full scope of vitamin D action during Mycobacterium tuberculosis (Mtb) infection is poorly understood. As macrophages are the primary site of Mtb infection and are sites of vitamin D signaling, we have used these cells to understand the molecular mechanisms underlying modulation of the immune response by the hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D). We found that the virul  ...[more]

Similar Datasets

2013-11-28 | GSE52819 | GEO
2016-07-01 | GSE82023 | GEO
2016-07-01 | E-GEOD-82023 | biostudies-arrayexpress
2016-02-20 | GSE78083 | GEO
2017-01-01 | GSE54765 | GEO
2016-02-20 | E-GEOD-78083 | biostudies-arrayexpress
2015-04-26 | E-GEOD-60102 | biostudies-arrayexpress
2021-10-01 | GSE179376 | GEO
2017-08-16 | PXD002347 | Pride
2014-07-01 | E-GEOD-57028 | biostudies-arrayexpress