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Transcriptome analysis of primary monocytes from HIV+ patients with differential responses to therapy

ABSTRACT: This study aimed at investigating the monocytic transcriptome distinction between patients with sustained virus suppression (BDL) and patients with virological failure during highly active antiretroviral therapy (HAART). This study provides the first transcriptomic distinctions in monocytes between viremic patients and BDLs on HAART. Our results reflected the outcome balanced between subversion of monocyte transcriptome by HIV and compensatory effect adapted by host cells. Total RNA obtained from primary monocytes from five HIV+ patients on HAART who sustainably controlled HIV below detection level (BDL), five HIV+ patients on HAART who consecutively experienced viremia and four healthy HIV sero-negative controls were compared against each other.

ORGANISM(S): Homo sapiens

SUBMITTER: Nitin Saksena

PROVIDER: E-GEOD-52900 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptome analysis of primary monocytes from HIV-positive patients with differential responses to antiretroviral therapy.

Wu Jing Qin JQ Sassé Tara Ruth TR Saksena Monica Miranda MM Saksena Nitin K NK

Virology journal 20131227

<h4>Background</h4>Despite the significant contributions of monocytes to HIV persistence, the HIV-monocyte interaction remains elusive. For patients on antiretroviral therapy, previous studies observed a virological suppression rate of >70% and suggested complete viral suppression as the primary goal. Although some studies have reported genetic dysregulations associated with HIV disease progression, research on ex vivo-derived monocytic transcriptomes from HIV+ patients with differential respons ...[more]

PMID: 24370116

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