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Genome-wide analysis of basal gene expression in pediatric acute lymphoblastic leukemia xenograft cells

ABSTRACT: Analysis of basal gene expression in patient-derived xenograft cells. A panel of pediatric T-, B- and MLL-ALL xenografts was utilized to further understand the biology of leukemia Total RNA was isolated from patient-derived xenograft cells. Array analysis was carried out on Illumina beadchip HT12

ORGANISM(S): Homo sapiens

SUBMITTER: Santi Suryani 

PROVIDER: E-GEOD-52991 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cell and molecular determinants of in vivo efficacy of the BH3 mimetic ABT-263 against pediatric acute lymphoblastic leukemia xenografts.

Suryani Santi S   Carol Hernan H   Chonghaile Triona Ni TN   Frismantas Viktoras V   Sarmah Chintanu C   High Laura L   Bornhauser Beat B   Cowley Mark J MJ   Szymanska Barbara B   Evans Kathryn K   Boehm Ingrid I   Tonna Elise E   Jones Luke L   Manesh Donya Moradi DM   Kurmasheva Raushan T RT   Billups Catherine C   Kaplan Warren W   Letai Anthony A   Bourquin Jean-Pierre JP   Houghton Peter J PJ   Smith Malcolm A MA   Lock Richard B RB  

Clinical cancer research : an official journal of the American Association for Cancer Research 20140710 17

<h4>Purpose</h4>Predictive biomarkers are required to identify patients who may benefit from the use of BH3 mimetics such as ABT-263. This study investigated the efficacy of ABT-263 against a panel of patient-derived pediatric acute lymphoblastic leukemia (ALL) xenografts and utilized cell and molecular approaches to identify biomarkers that predict in vivo ABT-263 sensitivity.<h4>Experimental design</h4>The in vivo efficacy of ABT-263 was tested against a panel of 31 patient-derived ALL xenogra  ...[more]

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