Cross-platform toxicogenomics for the prediction of nongenotoxic hepatocarcinogenesis in rat
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ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Johannes Eichner
PROVIDER: E-GEOD-53085 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Cross-platform toxicogenomics for the prediction of non-genotoxic hepatocarcinogenesis in rat.
Römer Michael M Eichner Johannes J Metzger Ute U Templin Markus F MF Plummer Simon S Ellinger-Ziegelbauer Heidrun H Zell Andreas A
PloS one 20140515 5
In the area of omics profiling in toxicology, i.e. toxicogenomics, characteristic molecular profiles have previously been incorporated into prediction models for early assessment of a carcinogenic potential and mechanism-based classification of compounds. Traditionally, the biomarker signatures used for model construction were derived from individual high-throughput techniques, such as microarrays designed for monitoring global mRNA expression. In this study, we built predictive models by integr ...[more]
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