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Notch signaling regulates neural crest differentiation from human pluripotent stem cells

ABSTRACT: The aim of the dataset was to study on genome-wide level the effect of Notch inhibition in gene expression on neural crest differentiation of human embryonic stem cells under chemically defined conditions. Total RNA from hESCs, hESC-derived neural crest, hESC-derived neural crest+DAPT, and hESC-derived neural stem cells was collected and compared at their global gene expression level. Samples from 3 biological replicates were analysed.

ORGANISM(S): Homo sapiens

SUBMITTER: Kartiek Kanduri

PROVIDER: E-GEOD-53203 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Notch signaling regulates the differentiation of neural crest from human pluripotent stem cells.

Noisa Parinya P Lund Carina C Kanduri Kartiek K Lund Riikka R Lähdesmäki Harri H Lahesmaa Riitta R Lundin Karolina K Chokechuwattanalert Hataiwan H Otonkoski Timo T Tuuri Timo T Raivio Taneli T

Journal of cell science 20140225 Pt 9

Neural crest cells are specified at the border between the neural plate and the epiderm. They are capable of differentiating into various somatic cell types, including craniofacial and peripheral nerve tissues. Notch signaling plays important roles during neurogenesis; however, its function during human neural crest development is poorly understood. Here, we generated self-renewing premigratory neural-crest-like cells (pNCCs) from human pluripotent stem cells (hPSCs) and investigated the roles o ...[more]

PMID: 24569875

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