Ontology highlight
ABSTRACT:
ORGANISM(S): Danio rerio
SUBMITTER: Philippe Collas
PROVIDER: E-GEOD-53209 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ostrup Olga O Reiner Andrew H AH Aleström Peter P Collas Philippe P
Biochimica et biophysica acta 20140928 11
Early embryo development constitutes a unique opportunity to study acquisition of epigenetic marks, including histone methylation. This study investigates the in vivo function and specificity of 3-deazaneplanocin A (DZNep), a promising anti-cancer drug that targets polycomb complex genes. One- to two-cell stage embryos were cultured with DZNep, and subsequently evaluated at the post-mid blastula transition stage for H3K27me3, H3K4me3 and H3K9me3 occupancy and enrichment at promoters using ChIP-c ...[more]