Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptome expression profile of embryonic liver and placenta tissue from BAHD1+/+ (WT) and BAHD1-/- (KO) mice at embryonic day E16.5

ABSTRACT: Comparisons of embryonic liver and placenta gene expression profiles of BAHD1-KO mice to those of wild-type littermate mice We used DNA microarrays to identify the repertoire of genes differentially expressed by ablation of the BAHD1 gene in embryos.

ORGANISM(S): Mus musculus

SUBMITTER: Hélène Bierne 

PROVIDER: E-GEOD-53442 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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BAHD1 is a vertebrate protein that promotes heterochromatin formation and gene repression in association with several epigenetic regulators. However, its physiological roles remain unknown. Here, we demonstrate that ablation of the Bahd1 gene results in hypocholesterolemia, hypoglycemia and decreased body fat in mice. It also causes placental growth restriction with a drop of trophoblast glycogen cells, a reduction of fetal weight and a high neonatal mortality rate. By intersecting transcriptome  ...[more]

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