Unknown,Transcriptomics,Genomics,Proteomics

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Epigenetic regulations in the IFNM-NM-3 signalling pathway: IFNM-NM-3-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes [RVPC3_DAC]


ABSTRACT: Reversible MHC class I deficiency on tumour cells is commonly caused by coordinated silencing of antigen-presenting machinery genes and restorable by IFNM-NM-3. Here we describe association of DNA demethylation of selected antigen-presenting machinery gene regulatory regions located in the MHC genomic locus (TAP-1, TAP-2, LMP-2, LMP-7) upon IFNM-NM-3 treatment with MHC class I upregulation on tumour cells. Our novel findings demonstrate that IFNM-NM-3 acts as an epigenetic modifier upregulating the expression of antigen-presenting machinery genes through DNA demethylation. Our data also cast more light on the role of DNA methylation in tumour cell escape from specific immunity. RVP3 cultured cells treated with DAC/TSA or nothing. 3 biological replicates per condition.

ORGANISM(S): Mus musculus

SUBMITTER: Milan Reinis 

PROVIDER: E-GEOD-53465 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Epigenetic regulations in the IFNγ signalling pathway: IFNγ-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes.

Vlková Veronika V   Štěpánek Ivan I   Hrušková Veronika V   Šenigl Filip F   Mayerová Veronika V   Šrámek Martin M   Šímová Jana J   Bieblová Jana J   Indrová Marie M   Hejhal Tomáš T   Dérian Nicolas N   Klatzmann David D   Six Adrien A   Reiniš Milan M  

Oncotarget 20140801 16


Downregulation of MHC class I expression on tumour cells, a common mechanism by which tumour cells can escape from specific immune responses, can be associated with coordinated silencing of antigen-presenting machinery genes. The expression of these genes can be restored by IFNγ. In this study we documented association of DNA demethylation of selected antigen-presenting machinery genes located in the MHC genomic locus (TAP-1, TAP-2, LMP-2, LMP-7) upon IFNγ treatment with MHC class I upregulation  ...[more]

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