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PRC2 coordinates lineage fidelity and DNA methylation during ESC differentiation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Laurie Boyer

PROVIDER: E-GEOD-53508 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Polycomb Repressive Complex 2 regulates lineage fidelity during embryonic stem cell differentiation.

Thornton Seraphim R SR Butty Vincent L VL Levine Stuart S SS Boyer Laurie A LA

PloS one 20141021 10

Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation (H3K27me3), an epigenetic modification associated with gene repression. H3K27me3 is enriched at the promoters of a large cohort of developmental genes in embryonic stem cells (ESCs). Loss of H3K27me3 leads to a failure of ESCs to properly differentiate, making it difficult to determine the precise roles of PRC2 during lineage commitment. Moreover, while studies suggest that PRC2 prevents DNA methylation, how thes ...[more]

PMID: 25333635

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