Methylation dynamics of mouse neuron by MeDIP-seq and MRE-seq
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Daofeng Li
PROVIDER: E-GEOD-53694 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Intermediate DNA methylation is a conserved signature of genome regulation.
Elliott GiNell G Hong Chibo C Xing Xiaoyun X Zhou Xin X Li Daofeng D Coarfa Cristian C Bell Robert J A RJ Maire Cecile L CL Ligon Keith L KL Sigaroudinia Mahvash M Gascard Philippe P Tlsty Thea D TD Harris R Alan RA Schalkwyk Leonard C LC Bilenky Misha M Mill Jonathan J Farnham Peggy J PJ Kellis Manolis M Marra Marco A MA Milosavljevic Aleksandar A Hirst Martin M Stormo Gary D GD Wang Ting T Costello Joseph F JF
Nature communications 20150218
The role of intermediate methylation states in DNA is unclear. Here, to comprehensively identify regions of intermediate methylation and their quantitative relationship with gene activity, we apply integrative and comparative epigenomics to 25 human primary cell and tissue samples. We report 18,452 intermediate methylation regions located near 36% of genes and enriched at enhancers, exons and DNase I hypersensitivity sites. Intermediate methylation regions average 57% methylation, are predominan ...[more]
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