Shugoshin biases chromosomes for biorientation through condensin recruitment to the pericentromere

ABSTRACT: To protect against aneuploidy, chromosomes must attach to microtubules from opposite poles (“biorientation”) prior to their segregation during mitosis. Biorientation relies on the correction of erroneous attachments by the aurora B kinase, which destabilizes kinetochore-microtubule attachments that lack tension. Incorrect attachments are also avoided because sister kinetochores are intrinsically biased towards capture by microtubules from opposite poles. Here we show that shugoshin acts as a pericentromeric adaptor that plays dual roles in biorientation in budding yeast. Shugoshin maintains the aurora B kinase at kinetochores that lack tension, thereby engaging the error correction machinery. Shugoshin also recruits the chromosome-organising complex, condensin, to the pericentromere. Peric

ORGANISM(S): Saccharomyces cerevisiae W303

SUBMITTER: Alastair Kerr 

PROVIDER: E-GEOD-53856 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress