Genome-wide gene expression profiling reveals unsuspected molecular alterations in Pemphigus Foliaceus

ABSTRACT: Pemphigus foliaceus (PF) is a complex autoimmune disease characterized by bullous skin lesions and the presence of antibodies against desmoglein 1. In this study we sought to contribute to a better understanding of the molecular processes in endemic PF, since the identification of factors that participate in the pathogenesis is a prerequisite for understanding its biological basis and may lead to novel therapeutic interventions. CD4+ T lymphocytes are central to the development of the disease. Therefore, we compared genome-wide gene expression profiles of peripheral CD4+ T cells of various PF patient subgroups with each other and with that of healthy individuals. The patients sample was subdivided in three groups: untreated patients with the generalized form of the disease, patients submit

ORGANISM(S): Homo sapiens

SUBMITTER: Danielle Malheiros 

PROVIDER: E-GEOD-53873 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress