Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Yan-Wei Hu
PROVIDER: E-GEOD-54039 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hu Yan-Wei YW Yang Jun-Yao JY Ma Xin X Chen Zhi-Ping ZP Hu Ya-Rong YR Zhao Jia-Yi JY Li Shu-Fen SF Qiu Yu-Rong YR Lu Jing-Bo JB Wang Yan-Chao YC Gao Ji-Juan JJ Sha Yan-Hua YH Zheng Lei L Wang Qian Q
Journal of lipid research 20140203 4
Accumulated evidence shows that G protein-coupled receptor 119 (GPR119) plays a key role in glucose and lipid metabolism. Here, we explored the effect of GPR119 on cholesterol metabolism and inflammation in THP-1 macrophages and atherosclerotic plaque progression in apoE(-/-) mice. We found that oxidized LDL (Ox-LDL) significantly induced long intervening noncoding RNA (lincRNA)-DYNLRB2-2 expression, resulting in the upregulation of GPR119 and ABCA1 expression through the glucagon-like peptide 1 ...[more]