Unknown,Transcriptomics,Genomics,Proteomics

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LncRNA/mRNA expression profiling for THP-1 macrophages and THP-1 macrophage-derived foam cells


ABSTRACT: By identifying differentially expressed LncRNAs/mRNAs in THP-1 macrophages and THP-1 macrophage-derived foam cells, we select some differentially expressed LncRNAs and explore their roles in atherosclerosis process. We already find that some LncRNA can effect cholesterol metabolism and level of inflammation factor, which may influence atherosclerosis process. In the study presented here, 6 human samples were used to acquire expression profiles, which provide futher insight into the pathologies of atherosclerosis

ORGANISM(S): Homo sapiens

SUBMITTER: Yan-Wei Hu 

PROVIDER: E-GEOD-54039 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis.

Hu Yan-Wei YW   Yang Jun-Yao JY   Ma Xin X   Chen Zhi-Ping ZP   Hu Ya-Rong YR   Zhao Jia-Yi JY   Li Shu-Fen SF   Qiu Yu-Rong YR   Lu Jing-Bo JB   Wang Yan-Chao YC   Gao Ji-Juan JJ   Sha Yan-Hua YH   Zheng Lei L   Wang Qian Q  

Journal of lipid research 20140203 4


Accumulated evidence shows that G protein-coupled receptor 119 (GPR119) plays a key role in glucose and lipid metabolism. Here, we explored the effect of GPR119 on cholesterol metabolism and inflammation in THP-1 macrophages and atherosclerotic plaque progression in apoE(-/-) mice. We found that oxidized LDL (Ox-LDL) significantly induced long intervening noncoding RNA (lincRNA)-DYNLRB2-2 expression, resulting in the upregulation of GPR119 and ABCA1 expression through the glucagon-like peptide 1  ...[more]

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