Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mouse liver: Control versus IL1-beta challenge, male and female

ABSTRACT: Transcriptional profiling of liver gene expression following IL1-beta challenge comparing male versus female mice IL1-beta versus no cytokine control, male and female. Biological replicates: 2 per sex per treatment protocol.

ORGANISM(S): Mus musculus

SUBMITTER: Arlin Rogers

PROVIDER: E-GEOD-54071 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Prolactin Prevents Hepatocellular Carcinoma by Restricting TRAF-Dependent Innate Immune Activation of c-Myc

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-03-07 | E-GEOD-55669 | biostudies-arrayexpress

Mouse liver: Control versus IL1-beta challenge, male and female

Project description:Transcriptional profiling of liver gene expression following IL1-beta challenge comparing male versus female mice

2014-02-01 | GSE54071 | GEO

Effect of prolactin and actinomycin D on gene expression in murine AML12 and Hepa 1-6 hepatocytes

Project description:Transcriptional profiling of murine hepatocyte gene expression following exposure to prolactin or actinomycin D Prolactin or actinomycin D-treated versus serum-free control cells: AML12 and Hepa 1-6. Biological replicates: 2 per cell line per treatment protocol.

2014-04-25 | E-GEOD-57072 | biostudies-arrayexpress

Transcription profiling of human thyroid cells exposed to INF-gamma and IL1-beta

Project description:Normal primary thyroid cells were incubated with , 100 IU/ml IFN-gamma, 50 IU/ml IL1-beta, or a combination of both IFN-gamma and IL1-beta for 24 or 72 hours. The experiment was repeated 5 times using thyroid cells from 5 different patients. RNA expression was analyzed using Affymetrix HG_U133A arrays for 3 of the thyroids, and HG_U133A_2.0 (small version of HG_U133A) arrays for 2 of the thyroids. Experiment Overall Design: Normal primary thyroid cells were incubated with , 100 IU/ml IFN-gamma, 50 IU/ml IL1-beta, or a combination of both IFN-gamma and IL1-beta for 24 or 72 hours. The experiment was repeated 5 times using thyroid cells from 5 different patients. One array was hybridized per sample (20 samples). Experiment Overall Design: The probe-set intensities with accompanying statistical analysis (2-way ANOVA) and the associated README file are included as Supplementary files.

2008-11-06 | E-GEOD-5054 | biostudies-arrayexpress

Effect of INF-gamma and IL1-beta on thyroid cells

Project description:Normal primary thyroid cells were incubated with vehicle, 100 IU/ml IFN-gamma, 50 IU/ml IL1-beta, or a combination of both IFN-gamma and IL1-beta for 24 or 72 hours. The experiment was repeated 5 times using thyroid cells from 5 different patients. RNA expression was analyzed using Affymetrix HG_U133A arrays for 3 of the thyroids, and HG_U133A_2.0 (small version of HG_U133A) arrays for 2 of the thyroids. Keywords: cytokine treatments

2007-08-24 | GSE5054 | GEO

Mus musculus

Project description:Mouse liver: Control versus IL1-beta challenge, male and female

| PRJNA234532 | ENA

Gene expression analysis of human liver in healthy adults

Project description:Transcriptional profiling of liver gene expression in adult women and men without primary liver disease Female versus male. Biological replicates: 7 per sex. This dataset is part of the TransQST collection.

2014-03-07 | E-GEOD-55668 | biostudies-arrayexpress

Epidermal keratinocytes and IFNg, TNFa and IL1 treatment

Project description:Cultured epidermal keratinocyte controls used for IFNg, TNFa and IL1 treatment. Keywords: other

2003-06-24 | GSE440 | GEO

Transcription profiling of cultured mouse astrocytes in response to stimulation with CCM (complete cytokine mix: TNF-alpha, IL1-beta and IFN-gamma) at 4hr and 16hr time points

Project description:Transcriptional activation of cultured mouse astrocytes in response to stimulation with CCM (complete cytokine mix: TNF-alpha, IL1-beta and IFN-gamma) at 4hr and 16hr time points.

2005-12-01 | E-MEXP-321 | biostudies-arrayexpress

Transcription profiling of human epidermal keratinocytes treated with IFN-gamma reveals IFN-gamma suppressed the expression of over 100 genes responsible for cell cycle, DNA replication and RNA metabolism.

Project description:Cultured epidermal keratinocyte controls used for IFNg, TNFa and IL1 treatment. Interferon (IFN)-gamma, is a multifunctional, immunomodulatory cytokine with cell type-specific antiviral activities, particularly important in skin, where it is implicated in many diseases ranging from warts to psoriasis and cancer. Since epidermis is our first line of defence against many viruses, we investigated the molecular processes regulated by IFN-gamma in keratinocytes using DNA microarrays. We identified the IFN-gamma-regulated keratinocyte-specific genes in keratinocytes, IFN-gamma-induced tight junction proteins, presumably to deny viruses paracellular routes of infection. Furthermore, differing from published data, we find that IFN-gamma suppressed the expression of keratinocytes differentiation markers including desmosomal proteins, cornified envelope components and suprabasal cytokeratins. Inhibition of differentiation may interfere with the epidermal tropism of viruses that require differentiating cells for growth, for example, papillomaviruses. As in other cell types, IFN-gamma induced HLA, cell adhesion and proteasome proteins, facilitating leukocyte attraction and antigen-presentation by keratinocytes. IFN-gamma also induced chemokine/cytokines specific for mononuclear cells. IFN-gamma suppressed the expression of over 100 genes responsible for cell cycle, DNA replication and RNA metabolism, thereby shutting down many nuclear processes and denying viruses a healthy cell in which to replicate. Thus, uniquely in keratinocytes, IFN-gamma initiates a well-organized molecular programme boosting host antiviral defences, obstructing viral entry, suppressing cell proliferation and impeding differentiation.

2007-10-26 | E-GEOD-440 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data