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Transcription profiling of mouse spinal cord and dorsal root ganglion to test the fundamental quantitative differences between central and peripheral nervous system transcriptomes

ABSTRACT: We used microarrays to test the fundamental quantitative differences between central and peripheral nervous system transcriptomes. Experiment Overall Design: 3 independent SC and 3 independent DRG samples were analyzed. Each sample contained material from 4 age-matched male C57B/6 mice.

ORGANISM(S): Mus musculus

SUBMITTER: Lijing Xu

PROVIDER: E-GEOD-5425 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Murine central and peripheral nervous system transcriptomes: comparative gene expression.

LeDoux Mark S MS Xu Lijing L Xiao Jianfeng J Ferrell Brett B Menkes Daniel L DL Homayouni Ramin R

Brain research 20060707 1

The central and peripheral nervous systems exhibit significant embryological, morphological, and functional differences. Moreover, the pathology of most acquired and hereditary neurological diseases preferentially targets specific components of the nervous system. In order to test the hypothesis that central and peripheral neural transcriptomes show fundamental quantitative differences, Affymetrix GeneChip expression arrays were used to compare murine lumbar spinal cord (SC) and dorsal root gang ...[more]

PMID: 16824496

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