Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Philippe Collas
PROVIDER: E-GEOD-54333 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lund Eivind E Oldenburg Anja R AR Collas Philippe P
Nucleic acids research 20140429 11
Nuclear lamins contact the genome at the nuclear periphery through large domains and are involved in chromatin organization. Among broad peak calling algorithms available to date, none are suited for mapping lamin-genome interactions genome wide. We disclose a novel algorithm, enriched domain detector (EDD), for analysis of broad enrichment domains from chromatin immunoprecipitation (ChIP)-seq data. EDD enables discovery of genomic domains interacting with broadly distributed proteins, such as A ...[more]