Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human sequential breast cancer biopsies during letrozole treatment

ABSTRACT: In the present investigation, we have exploited the opportunity provided by neoadjuvant treatment of a group of postmenopausal women with large operable or locally advanced breast cancer (in which therapy is given with the primary tumour remaining within the breast) to take sequential biopsies of the same cancers before and after 10-14 days treatment with letrozole. RNA extracted from the biopsies has been subjected to Affymetrix microarray analysis and the data from paired biopsies interrogated to discover genes whose expression is most influenced by oestrogen deprivation. Experiment Overall Design: biopsies were taken from the same subjects both pretreatment and after 10-14 days Letrozol, 2.5 mg/day, oral

ORGANISM(S): Homo sapiens

SUBMITTER: John Walker 

PROVIDER: E-GEOD-5462 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Changes in breast cancer transcriptional profiles after treatment with the aromatase inhibitor, letrozole.

Miller William R WR   Larionov Alexey A AA   Renshaw Lorna L   Anderson Thomas J TJ   White Sharon S   Murray Juliette J   Murray Emma E   Hampton Garret G   Walker John R JR   Ho Steven S   Krause Andreas A   Evans Dean B DB   Dixon John Michael JM  

Pharmacogenetics and genomics 20071001 10

<h4>Objective</h4>The aim of the study was to identify changes in tumour expression profiling associated with short-term therapy of breast cancer patients with letrozole.<h4>Experimental design</h4>Microarray analysis was performed on RNA extracted from paired tumour core biopsies taken before and after 14 days of treatment with letrozole (2.5 mg/daily) in 58 patients. Changes in expression profile were identified by three different approaches on the basis of frequency of changes, magnitude of c  ...[more]

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