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Molecular Analysis and Characteristics of Ethnic Skin

ABSTRACT: In this study, we used microarray analysis to investigate molecular differences underlying the determination of pigmentation in various skin types, and we used immunohistochemistry to validate the expression patterns of several interesting targets that were identified. Whole skin gene expression profile were investigated in three ethnic groups:1) Caucasian 2)Asian 3)African. In each group, 4 mm whole skin punch biopsies were taken from forearm of 10 subjects, and gene expression level were tested by agilent whole human genome microarray. Samples with mRNA degraded: African_skin_03, Asian_skin_02, Asian_skin_06, and Caucasian_skin_7.

ORGANISM(S): Homo sapiens

SUBMITTER: Vincent Hearing

PROVIDER: E-GEOD-54638 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Epidermal gene expression and ethnic pigmentation variations among individuals of Asian, European and African ancestry.

Yin Lanlan L Coelho Sergio G SG Ebsen Dominik D Smuda Christoph C Mahns Andre A Miller Sharon A SA Beer Janusz Z JZ Kolbe Ludger L Hearing Vincent J VJ

Experimental dermatology 20141001 10

Differences in visible skin pigmentation give rise to the wide variation of skin colours seen in racial/ethnic populations. Skin pigmentation is important not only from cosmetic and psychological points of view, but more importantly because of its implications for the risk of all types of skin cancers, on photoaging, etc. Despite differences in those parameters in Caucasian and Asian skin types, they are remarkably similar in their production and distribution of melanins, and the mechanism(s) un ...[more]

PMID: 25055985

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