Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: H.G. Stunnenberg
PROVIDER: E-GEOD-54693 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
PloS one 20140613 6
MBD2 is a subunit of the NuRD complex that is postulated to mediate gene repression via recruitment of the complex to methylated DNA. In this study we adopted an MBD2 tagging-approach to study its genome wide binding characteristics. We show that in vivo MBD2 is mainly recruited to CpG island promoters that are highly methylated. Interestingly, MBD2 binds around 1 kb downstream of the transcription start site of a subset of ∼ 400 CpG island promoters that are characterized by the presence of act ...[more]