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Distinct functional programming of human fetal and adult monocytes [set 2]

ABSTRACT: Microarray profiling of unstimulated and IFNg-stimulated human fetal and adult bone marrow classical monocytes Classical monocytes were stimulated or no with IFNg for 4 hours, sort purified, RNA isolated, and amplified. 4 of each sample was collected and used

ORGANISM(S): Homo sapiens

SUBMITTER: Joseph McCune

PROVIDER: E-GEOD-54817 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Distinct functional programming of human fetal and adult monocytes.

Krow-Lucal Elisabeth R ER Kim Charles C CC Burt Trevor D TD McCune Joseph M JM

Blood 20140211 12

Preterm birth affects 1 out of 9 infants in the United States and is the leading cause of long-term neurologic handicap and infant mortality, accounting for 35% of all infant deaths in 2008. Although cytokines including interferon-γ (IFN-γ), interleukin-10 (IL-10), IL-6, and IL-1 are produced in response to in utero infection and are strongly associated with preterm labor, little is known about how human fetal immune cells respond to these cytokines. We demonstrate that fetal and adult CD14(+)CD ...[more]

PMID: 24518760

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