Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Assam El-Osta
PROVIDER: E-GEOD-54912 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Rafehi Haloom H Balcerczyk Aneta A Lunke Sebastian S Kaspi Antony A Ziemann Mark M Kn Harikrishnan H Okabe Jun J Khurana Ishant I Ooi Jenny J Khan Abdul Waheed AW Du Xiao-Jun XJ Chang Lisa L Haviv Izhak I Keating Samuel T ST Karagiannis Tom C TC El-Osta Assam A El-Osta Assam A
Genome research 20140414 8
HDAC inhibitors can regulate gene expression by post-translational modification of histone as well as nonhistone proteins. Often studied at single loci, increased histone acetylation is the paradigmatic mechanism of action. However, little is known of the extent of genome-wide changes in cells stimulated by the hydroxamic acids, TSA and SAHA. In this article, we map vascular chromatin modifications including histone H3 acetylation of lysine 9 and 14 (H3K9/14ac) using chromatin immunoprecipitatio ...[more]