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Transcription profiling of livers from mice overexpress ABCA1 in LDL receptor -/- genetic background to characterize the effects of ABCA1 overexpression.

ABSTRACT: Changes in the transcript profile due to ABCA1 expression in murine liver samples was evaluated in LDL receptor -/- genetic backgrounds. Experiment Overall Design: Case (ABCA1-transgenic) versus control (wild-type) design with 4 biological replicates per condition

ORGANISM(S): Mus musculus

SUBMITTER: Eric Billings

PROVIDER: E-GEOD-5496 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis.

Joyce Charles W CW Wagner Elke M EM Basso Federica F Amar Marcelo J MJ Freeman Lita A LA Shamburek Robert D RD Knapper Catherine L CL Syed Jafri J Wu Justina J Vaisman Boris L BL Fruchart-Najib Jamila J Billings Eric M EM Paigen Beverly B Remaley Alan T AT Santamarina-Fojo Silvia S Brewer H Bryan HB

The Journal of biological chemistry 20060823 44

The identification of ABCA1 as a key transporter responsible for cellular lipid efflux has led to considerable interest in defining its role in cholesterol metabolism and atherosclerosis. In this study, the effect of overexpressing ABCA1 in the liver of LDLr-KO mice was investigated. Compared with LDLr-KO mice, ABCA1-Tg x LDLr-KO (ABCA1-Tg) mice had significantly increased plasma cholesterol levels, mostly because of a 2.8-fold increase in cholesterol associated with a large pool of apoB-lipopro ...[more]

PMID: 16928680

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