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Dendritic Cell Fate is Determined by BCL11A

ABSTRACT: Here we confirm an essential requirement for the BCL11A transcription factor in fetal pDC development, and for the first time demonstrate this lineage specific requirement in the adult organism. Genome-wide analyses of BCL11A DNA binding and expression revealed that BCL11A regulates transcription of E2-2 and other pDC differentiation modulators including ID2 and MTG16. Our results identify BCL11A as an essential, lineage-specific factor that regulates pDC development. ChIP sequenicng was performed for a transcription factor of BCL11A in Cal1 cell line. Input was sequenced and used as a control.

ORGANISM(S): Homo sapiens

SUBMITTER: Bum-Kyu Lee

PROVIDER: E-GEOD-55043 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Dendritic cell fate is determined by BCL11A.

Ippolito Gregory C GC Dekker Joseph D JD Wang Yui-Hsi YH Lee Bum-Kyu BK Shaffer Arthur L AL Lin Jian J Wall Jason K JK Lee Baeck-Seung BS Staudt Louis M LM Liu Yong-Jun YJ Iyer Vishwanath R VR Tucker Haley O HO

Proceedings of the National Academy of Sciences of the United States of America 20140303 11

The plasmacytoid dendritic cell (pDC) is vital to the coordinated action of innate and adaptive immunity. pDC development has not been unequivocally traced, nor has its transcriptional regulatory network been fully clarified. Here we confirm an essential requirement for the BCL11A transcription factor in fetal pDC development, and demonstrate this lineage-specific requirement in the adult organism. Furthermore, we identify BCL11A gene targets and provide a molecular mechanism for its action in p ...[more]

PMID: 24591644

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Dendritic Cell Fate is Determined by BCL11A

Project description:Here we confirm an essential requirement for the BCL11A transcription factor in fetal pDC development, and for the first time demonstrate this lineage specific requirement in the adult organism. Genome-wide analyses of BCL11A DNA binding and expression revealed that BCL11A regulates transcription of E2-2 and other pDC differentiation modulators including ID2 and MTG16. Our results identify BCL11A as an essential, lineage-specific factor that regulates pDC development.

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