Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Bum-Kyu Lee
PROVIDER: E-GEOD-55043 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ippolito Gregory C GC Dekker Joseph D JD Wang Yui-Hsi YH Lee Bum-Kyu BK Shaffer Arthur L AL Lin Jian J Wall Jason K JK Lee Baeck-Seung BS Staudt Louis M LM Liu Yong-Jun YJ Iyer Vishwanath R VR Tucker Haley O HO
Proceedings of the National Academy of Sciences of the United States of America 20140303 11
The plasmacytoid dendritic cell (pDC) is vital to the coordinated action of innate and adaptive immunity. pDC development has not been unequivocally traced, nor has its transcriptional regulatory network been fully clarified. Here we confirm an essential requirement for the BCL11A transcription factor in fetal pDC development, and demonstrate this lineage-specific requirement in the adult organism. Furthermore, we identify BCL11A gene targets and provide a molecular mechanism for its action in p ...[more]