Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Marcin Cieslik
PROVIDER: E-GEOD-55062 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Asangani Irfan A IA Dommeti Vijaya L VL Wang Xiaoju X Malik Rohit R Cieslik Marcin M Yang Rendong R Escara-Wilke June J Wilder-Romans Kari K Dhanireddy Sudheer S Engelke Carl C Iyer Mathew K MK Jing Xiaojun X Wu Yi-Mi YM Cao Xuhong X Qin Zhaohui S ZS Wang Shaomeng S Feng Felix Y FY Chinnaiyan Arul M AM
Nature 20140423 7504
Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. Progression to CRPC after androgen ablation therapy is predominantly driven by deregulated androgen receptor (AR) signalling. Despite the success of recently approved therapies targeting AR signalling, such as abiraterone and second-generation anti-androgens including MDV3100 (also known as enzalutamide), durable responses are limited, presumably owing to acquired resistance. Recently, JQ1 a ...[more]