Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Larry Moss
PROVIDER: E-GEOD-55078 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Tessem Jeffery S JS Moss Larry G LG Chao Lily C LC Arlotto Michelle M Lu Danhong D Jensen Mette V MV Stephens Samuel B SB Tontonoz Peter P Hohmeier Hans E HE Newgard Christopher B CB
Proceedings of the National Academy of Sciences of the United States of America 20140324 14
Loss of functional β-cell mass is a hallmark of type 1 and type 2 diabetes, and methods for restoring these cells are needed. We have previously reported that overexpression of the homeodomain transcription factor NK6 homeobox 1 (Nkx6.1) in rat pancreatic islets induces β-cell proliferation and enhances glucose-stimulated insulin secretion, but the pathway by which Nkx6.1 activates β-cell expansion has not been defined. Here, we demonstrate that Nkx6.1 induces expression of the nuclear receptor ...[more]