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Identification of a novel biomarker serum miRNA from the patients with colorectal cancer (CRC).

ABSTRACT: Serum microRNAs (miRNAs) have been shown to have a potential for cancer diagnosis lately. The main objective of this study is to identify a novel biomarker serum miRNA from the patients with colorectal cancer (CRC). Microarray analysis of miRNA expression was performed using paired pre- and post- operative serum from 10 CRC patients. Two miRNAs (let-7a, miR-199a-3p) decreased significantly in the post-operative serum when compared to pre-operative serum (P=0.015 and 0.029, respectively). Microarrays were performed for paired pre- and post- operative serum from 10 CRC patients.

ORGANISM(S): Homo sapiens

SUBMITTER: Daisuke Okuzaki

PROVIDER: E-GEOD-55139 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Circulating miR-199a-3p as a novel serum biomarker for colorectal cancer.

Nonaka Ryoji R Nishimura Junichi J Kagawa Yoshinori Y Osawa Hideki H Hasegawa Junichi J Murata Kohei K Okamura Shu S Ota Hirofumi H Uemura Mamoru M Hata Taishi T Takemasa Ichiro I Mizushima Tsunekazu T Okuzaki Daisuke D Yamamoto Hirofumi H Doki Yuichiro Y Mori Masaki M

Oncology reports 20140924 6

Serum microRNAs (miRNAs) have been shown to have potential for cancer diagnosis. The main objective of the present study was to identify a novel serum miRNA biomarker from patients with colorectal cancer (CRC). Microarray analysis of miRNA expression was performed using paired pre-operative and post-operative serum from 10 CRC patients. Expression of two miRNAs (let-7a and miR-199a-3p) was significantly decreased in the post-operative serum when compared to levels in the pre-operative serum (P=0 ...[more]

PMID: 25269744

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