Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Takeshi Egawa
PROVIDER: E-GEOD-55227 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Blood 20140327 19
Runx1 and Cbfβ are critical for the establishment of definitive hematopoiesis and are implicated in leukemic transformation. Despite the absolute requirements for these factors in the development of hematopoietic stem cells and lymphocytes, their roles in the development of bone marrow progenitor subsets have not been defined. Here, we demonstrate that Cbfβ is essential for the development of Flt3(+) macrophage-dendritic cell (DC) progenitors in the bone marrow and all DC subsets in the peripher ...[more]