Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Xianlong Li
PROVIDER: E-GEOD-55249 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wen Lu L Li Xianlong X Yan Liying L Tan Yuexi Y Li Rong R Zhao Yangyu Y Wang Yan Y Xie Jingcheng J Zhang Yan Y Song Chunxiao C Yu Miao M Liu Xiaomeng X Zhu Ping P Li Xiaoyu X Hou Yu Y Guo Hongshan H Wu Xinglong X He Chuan C Li Ruiqiang R Tang Fuchou F Qiao Jie J
Genome biology 20140304 3
<h4>Background</h4>5-methylcytosine (mC) can be oxidized by the tet methylcytosine dioxygenase (Tet) family of enzymes to 5-hydroxymethylcytosine (hmC), which is an intermediate of mC demethylation and may also be a stable epigenetic modification that influences chromatin structure. hmC is particularly abundant in mammalian brains but its function is currently unknown. A high-resolution hydroxymethylome map is required to fully understand the function of hmC in the human brain.<h4>Results</h4>We ...[more]