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A human sleep homeostasis phenotype in mice expressing a primate-specific PER3 variable-number tandem-repeat coding-region polymorphism


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Emma Laing 

PROVIDER: E-GEOD-55255 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A human sleep homeostasis phenotype in mice expressing a primate-specific PER3 variable-number tandem-repeat coding-region polymorphism.

Hasan Sibah S   van der Veen Daan R DR   Winsky-Sommerer Raphaelle R   Hogben Alexandra A   Laing Emma E EE   Koentgen Frank F   Dijk Derk-Jan DJ   Archer Simon N SN  

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20140227 6


In humans, a primate-specific variable-number tandem-repeat (VNTR) polymorphism (4 or 5 repeats 54 nt in length) in the circadian gene PER3 is associated with differences in sleep timing and homeostatic responses to sleep loss. We investigated the effects of this polymorphism on circadian rhythmicity and sleep homeostasis by introducing the polymorphism into mice and assessing circadian and sleep parameters at baseline and during and after 12 h of sleep deprivation (SD). Microarray analysis was  ...[more]

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