Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ravindra B Chalamalasetty
PROVIDER: E-GEOD-55263 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Chalamalasetty Ravindra B RB Garriock Robert J RJ Dunty William C WC Kennedy Mark W MW Jailwala Parthav P Si Han H Yamaguchi Terry P TP
Development (Cambridge, England) 20141101 22
Neuromesodermal (NM) stem cells generate neural and paraxial presomitic mesoderm (PSM) cells, which are the respective progenitors of the spinal cord and musculoskeleton of the trunk and tail. The Wnt-regulated basic helix-loop-helix (bHLH) transcription factor mesogenin 1 (Msgn1) has been implicated as a cooperative regulator working in concert with T-box genes to control PSM formation in zebrafish, although the mechanism is unknown. We show here that, in mice, Msgn1 alone controls PSM differen ...[more]