Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Susana Kalko
PROVIDER: E-GEOD-55304 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Martínez Débora D Pentinat Thais T Ribó Sílvia S Daviaud Christian C Bloks Vincent W VW Cebrià Judith J Villalmanzo Nuria N Kalko Susana G SG Ramón-Krauel Marta M Díaz Rubén R Plösch Torsten T Tost Jörg J Jiménez-Chillarón Josep C JC
Cell metabolism 20140501 6
Obesity and type 2 diabetes have a heritable component that is not attributable to genetic factors. Instead, epigenetic mechanisms may play a role. We have developed a mouse model of intrauterine growth restriction (IUGR) by in utero malnutrition. IUGR mice developed obesity and glucose intolerance with aging. Strikingly, offspring of IUGR male mice also developed glucose intolerance. Here, we show that in utero malnutrition of F1 males influenced the expression of lipogenic genes in livers of F ...[more]