Unknown,Transcriptomics,Genomics,Proteomics

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MicroRNA Expression Profiles of Patients with Biochemically Recurrent Prostate Cancer


ABSTRACT: It is of paramount importance to unravel the molecular mechanisms underlying PCa progression to develop novel diagnostic and therapeutic approaches. MicroRNA (miRNA) profiling through microarrays is an invaluable tool to identify a miRNA signature, which is required to determine the general and specific expression alterations between distinct types of tissues. In this study, it is aimed to compare the miRNA profile of recurrent and non-recurrent prostate tumor tissues to explore a possible involvement of miRNAs in PCa progression.

ORGANISM(S): Homo sapiens

SUBMITTER: Chad Creighton 

PROVIDER: E-GEOD-55323 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

miR-1 and miR-133b are differentially expressed in patients with recurrent prostate cancer.

Karatas Omer Faruk OF   Guzel Esra E   Suer Ilknur I   Ekici Isin D ID   Caskurlu Turhan T   Creighton Chad J CJ   Ittmann Michael M   Ozen Mustafa M  

PloS one 20140626 6


Prostate cancer (PCa) is currently the most frequently diagnosed malignancy in the western countries. It is more prevalent in older men with 75% of the incident cases above 65 years old. After radical prostatectomy, approximately 30% of men develop clinical recurrence with elevated serum prostate-specific antigen levels. Therefore, it is important to unravel the molecular mechanisms underlying PCa progression to develop novel diagnostic/therapeutic approaches. In this study, it is aimed to compa  ...[more]

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