Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Marvin Jens
PROVIDER: E-GEOD-55324 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Rybak-Wolf Agnieszka A Jens Marvin M Murakawa Yasuhiro Y Herzog Margareta M Landthaler Markus M Rajewsky Nikolaus N
Cell 20141101 5
The endoribonuclease Dicer is known for its central role in the biogenesis of eukaryotic small RNAs/microRNAs. Despite its importance, Dicer target transcripts have not been directly mapped. Here, we apply biochemical methods to human cells and C. elegans and identify thousands of Dicer-binding sites. We find known and hundreds of additional miRNAs with high sensitivity and specificity. We also report structural RNAs, promoter RNAs, and mitochondrial transcripts as Dicer targets. Interestingly, ...[more]