Unknown,Transcriptomics,Genomics,Proteomics

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RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: michael lie-a-ling 

PROVIDER: E-GEOD-55335 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence.

Lie-A-Ling Michael M   Marinopoulou Elli E   Li Yaoyong Y   Patel Rahima R   Stefanska Monika M   Bonifer Constanze C   Miller Crispin C   Kouskoff Valerie V   Lacaud Georges G  

Blood 20140731 11


During ontogeny, the transcription factor RUNX1 governs the emergence of definitive hematopoietic cells from specialized endothelial cells called hemogenic endothelium (HE). The ultimate consequence of this endothelial-to-hematopoietic transition is the concomitant activation of the hematopoietic program and downregulation of the endothelial program. However, due to the rare and transient nature of the HE, little is known about the initial role of RUNX1 within this population. We, therefore, dev  ...[more]

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