Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: michael lie-a-ling
PROVIDER: E-GEOD-55335 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lie-A-Ling Michael M Marinopoulou Elli E Li Yaoyong Y Patel Rahima R Stefanska Monika M Bonifer Constanze C Miller Crispin C Kouskoff Valerie V Lacaud Georges G
Blood 20140731 11
During ontogeny, the transcription factor RUNX1 governs the emergence of definitive hematopoietic cells from specialized endothelial cells called hemogenic endothelium (HE). The ultimate consequence of this endothelial-to-hematopoietic transition is the concomitant activation of the hematopoietic program and downregulation of the endothelial program. However, due to the rare and transient nature of the HE, little is known about the initial role of RUNX1 within this population. We, therefore, dev ...[more]